When Professor Marsh disappears while searching for the lost city of Lukachukai, his daughter enlists the help of the Three Mesquiteers.
Ten years after the natives murdered her family, Iris hires two men to wipe out the whole lot, which happens to now include her sister Cynthia.
Mildred is traveling West in search of her long-lost father when she catches the roving eye of wicked dance-hall proprietor "Hawk" Kent. She turns him down flat and Kent has his henchman Blaze frame her in a crime. To keep herself out of jail, Mildred is compelled to work in Kent's dive, until the gallant Jack comes to her rescue.
Homesteaders battle a cattle baron, who is trying to drive them off the lands they have settled on so his cattle will be able to graze on it.
Willie Clever, city born and bred, having been spoiled with plenty of money, thinks he knows it all, or nearly all. His father buys a ranch in Arizona and sends Willie out to run the business. He comes with "all the fixin's," and has not been on the place an hour before he tries to run, or reform the outfit. The cowboys decide he needs some experience.
Convicted killer Jim Holden is rescued from the sheriff by his gang, led by Mason and Riley. He is out to get the Hathaway Stage superintendent George Bannister, who was responsible for his conviction and learns the Bannister, his niece (Kay) and Hal Hathaway, son of the stage line owner, are on a cross-country stage. Johnny, a rancher, and Waco, local stage representative head for the stage to warn the passengers, including entertainer Paradise Flo and coffin salesman Pennypacker. Hal takes the stage into Holdin. Johnny and Waco rescue Hal and Bannister before the gang succeeds in hanging the pair.
Escalating tensions within a frontier town besieged by outlaws.
Steve Driscoll arrives to help a friend who is trying to bring in an oil well. He finds that the well has been blown up and the workers have quit. He gets the workers back on the job and orders a new drill bit . When the drill bit is stolen he organizes the townspeople to invest in the well. But when the money is collected, a fake Durango Kid shows up to take it and flee
Cowboy Tim McCoy becomes an instrument of revenge when he discovers his parents have been killed.
Dale and Helen Brais are a marriage of farmers who subsist on what little they manage to get from their land. One stormy night, a stranger enters their home to rob and Dale kills him incidentally. The intruder is Red Burket, head of a band that is dedicated to sabotage the new railway line and there is a bounty on his head of $20,000. What seems the solution to the problems of the couple becomes the beginning of a nightmare.
A Canadian Mountie pursues an outlaw across the border into the America...
John Shefford is looking for his uncle Venters who years ago found a hidden valley and lived there with Jane Withersteen and young Fay Larkin. He finds Kay, now grown, who tells John that Willets and his men got into the nearly inaccessible valley and she has agreed to marry him to save the lives of the other two. John and Fay head for the valley with Willets and with his men right behind.
Winters is after the Brand ranch, and his man Brett who is foreman there is rustling the Brand stock. But Tom is on to their game and breaks up their attempt to buy the ranch. When they plan to rustle their horses, Tom must not only rescue Danny Brand, who is their prisoner, but stop the rustlers.
Hoppy, California, and Lucky travel to Mesa City for a short vacation. California buys new clothes and carrying his old ones in a suitcase, bumps into escaping bank robbers in the dark. His suitcase gets switched with that of the robbers and he is seen with the money. Hoppy must find the money that has mysteriously disappeared and also the robbers so that he can clear California who is now in jail.
Montana Rivers finally escapes her father who had forced her to wear men's clothing and help in robbing and cheating. She is taken in by friendly Indians and stays at their camp. Later, Akkomi, chief of the tribe, asks his friend Dan Overton to take the girl as it is not good for her to remain in the camp. Dan provides for "Tana" and falls in love with her but, because of her past, she keeps him at a distance. Jim Harris comes by and recognizes Tana as the boy robber, but when he attempts to blacken her past, Dan gives him a beating which paralyzes him. Jim then stays on with Dan, who regrets his hastiness. Eventually Tana's father appears and demands that Tana go away with him. She refuses but also does not tell Dan of this trouble.
An Indian girl is almost raped by Civil War soldiers while hunting. A general prevents worse and when the general's adjutant is badly wounded, she gives him life with the help of a snake's venom. But the poison changes the officer.
Doan is trying to get control of the valley by having his night riders drive the ranchers out. Jack Benson hires on at the Williams ranch, the one ranch Doan must have. When Benson learns that Doan is the boss of the night riders, he joins up with him. He has a plan that both saves Williams' ranch and also brings Doan to justice.
Nancy Raynor (Georgia Hale) is arriving from the East to see her dying uncle. Clint Beasley (Oland) and his gang are determined to kidnap her before she reaches him.
Sundown in Santa Fe is an adventure film directed by R.G. Springsteen in 60. A dagger has been left in every robbery by Walter Durant, fugitive leader of the President Lincoln murder ring. Rocky is sent to Santa Fe to find Durant and arrest him and the gang of outlaws he controls. Rocky soon finds that the information for every robbery comes from Tom, who is the son of the sheriff. But Rocky has to arrest the whole gang, and he does not know who is part of the gang and where Durant may be hiding.
A short Western in which a group of settlers are ambushed and slain by Indians. A girl escapes the massacre, and flees with the gold digger Jim. After this adventure, a romance begins between Jim and the girl.
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