World War II soldier-turned-U.S. Marshal Teddy Daniels investigates the disappearance of a patient from a hospital for the criminally insane, but his efforts are compromised by troubling visions and a mysterious doctor.
In late 1940s Los Angeles, Easy Rawlins is an unemployed black World War II veteran with few job prospects. At a bar, Easy meets DeWitt Albright, a mysterious white man looking for someone to investigate the disappearance of a missing white woman named Daphne Monet, who he suspects is hiding out in one of the city's black jazz clubs. Strapped for money and facing house payments, Easy takes the job, but soon finds himself in over his head.
Zach Riley is a psychiatrist, who leaves a job at a prestigious university, to take up a job at the privately run mental institution, Millwood. What he doesn't reveal at the time of his appointment is that this was the very place where his novelist father, T.L. Pierson, spent many years of his life.
In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly and the son of a famous virus expert who may hold the key to the Army of the 12 Monkeys; thought to be responsible for unleashing the killer disease.
Professor James Murray begins work compiling words for the first edition of the Oxford English Dictionary in the mid 19th century, and receives over 10,000 entries from a patient at Broadmoor Criminal Lunatic Asylum, Dr. William Minor.
Clarice Starling is a top student at the FBI's training academy. Jack Crawford wants Clarice to interview Dr. Hannibal Lecter, a brilliant psychiatrist who is also a violent psychopath, serving life behind bars for various acts of murder and cannibalism. Crawford believes that Lecter may have insight into a case and that Starling, as an attractive young woman, may be just the bait to draw him out.
After an accident, acclaimed novelist Paul Sheldon is rescued by a nurse who claims to be his biggest fan. Her obsession takes a dark turn when she holds him captive in her remote Colorado home and forces him to write back to life the popular literary character he killed off.
The wife of a photojournalist sets out to discover why he came home from a recent assignment without his colleague.
A mentally disturbed man takes residence in a halfway house. His mind gradually slips back into the realm created by his illness, where he replays a key part of his childhood.
New York City, 1957. Lionel Essrog, a private detective living with Tourette syndrome, tries to solve the murder of his mentor and best friend, armed only with vague clues and the strength of his obsessive mind.
After civilization succumbs to a deadly pandemic and his wife is murdered, a special forces soldier abandons his duty and becomes a hermit in the Nordic wilderness. Years later, a wounded woman appears on his doorstep. She's escaped from a lab and her pursuers believe her blood is the key to a worldwide cure. He's hesitant to get involved, but all doubts are cast aside when he discovers her pursuer is none other than Commander Stone, the man that murdered his wife some years ago.
A psychiatrist, Martin Dysart, investigates the savage blinding of six horses with a metal spike in a stable in Hampshire, England. The atrocity was committed by an unassuming seventeen-year-old stable boy named Alan Strang, the only son of an opinionated but inwardly-timid father and a genteel, religious mother. As Dysart exposes the truths behind the boy's demons, he finds himself face-to-face with his own.
Paul is a down-on-his-luck screenwriter who picks up a drifter and offers him a place to stay. However, when the deranged stranger takes Paul hostage and forces him to write, their unhinged relationship brings buried secrets to light.
On a lavish yacht for an assignment, a journalist sees a passenger go overboard. But when no one believes her, she risks her life to uncover the truth.
Charles Dobbs is a British secret agent investigating the apparent suicide of Foreign Office official Samuel Fennan. Dobbs suspects that Fennan's wife, Elsa, a survivor of a Nazi Germany extermination camp, might have some clues, but other officials want Dobbs to drop the case. So Dobbs hires a retiring inspector, Mendel, to quietly make inquiries. Dobbs isn't at all sure as there are a number of anomalies that simply can't be explained away. Dobbs is also having trouble at home with his errant wife, whom he very much loves, having frequent affairs. He's also pleased to see an old friend, Dieter Frey, who he recruited after the war. With the assistance of a colleague and a retired policeman, Dobbs tries to piece together just who is the spy and who in fact assassinated Fennan.
Haunted by her past, a nurse travels from England to a remote Irish village in 1862 to investigate a young girl's supposedly miraculous fast.
Deputy Sheriff Lou Ford is a pillar of the community in his small west Texas town, patient and apparently thoughtful. Some people think he is a little slow and maybe boring, but that is the worst they say about him. But then nobody knows about what Lou calls his "sickness": He is a brilliant, but disturbed sociopathic sadist.
Psychiatrist Sam Foster has a new patient, Henry Letham, who claims to be suicidal. In trying to diagnose him, Sam visits Henry's prior therapist and also finds Henry's mother -- even though Henry has said that he murdered both of his parents. As reality starts to contradict fact, Sam spirals into an unstable mental state. Then he finds a clue as to how and when Henry may try to kill himself, and races to try to stop him.
Dr. Martin Blake, who has spent his life looking for respect, meets an 18-year-old patient named Diane, suffering from a kidney infection, and gets a much-needed boost of self-esteem. However, when her health starts improving, Martin fears losing her, so he begins tampering with her treatment, keeping Diane sick and in the hospital right next to him.
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